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ω-Tbo-IT1 has been isolated from the venom of the Tibellus oblongus spider. ω-Tbo-IT1 is a selective blocker of insects calcium channels. It has been shown that ω-Tbo-IT1 has a potent insect toxicity with LD50 19 μg/g on house fly Musca domestica larvae and LD50 20 μg/g on juvenile Gromphadorhina portentosa cockroaches. Electrophysiological experiments revealed a reversible inhibition of evoked excitatory postsynaptic currents in blow fly Calliphora vicina neuromuscular junctions with an IC50 value 40 ± 10 nM.
AA sequence: CASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM
Disulfide bonds: Cys1-Cys21; Cys8-Cys25; Cys20-Cys40
Length (aa): 41
Formula: C171H285N61O53S9
Molecular Weight: 4331,74 g/mol
CAS number: NA
Source: Synthetic
Purity rate: > 95 %
Mikov A., et al. (2015) ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom. Sci Rep.
Novel disulfide-containing polypeptide toxin was discovered in the venom of the Tibellus oblongus spider. We report on isolation, spatial structure determination and electrophysiological characterization of this 41-residue toxin, called ω-Tbo-IT1. It has an insect-toxic effect with LD50 19 μg/g in experiments on house fly Musca domestica larvae and with LD50 20 μg/g on juvenile.
PMC: 4661699
