Ssm6a centipede toxin information

μ-SLPTX-Ssm6a, a peptide isolated from the venom of the centipede S. subspinipes mutilans, was recently described to potently inhibit hNav1.7 with an IC50 of 25 nM [1]. Other results [2] and Smartox’s tests did not confirm the Nav1.7 inhibitory effect of this peptide for now.

Smartox Biotechnology offers other validated Nav1.7 blockers:

• ProTx-II – Protoxin-2
• Huwentoxin-IV
• Hainantoxin-III
• Hainantoxin-IV
• GsAF-1
• GsAF-2

[1] Yang S.,  et al.  (2013)  Discovery of a selective Nav1.7 inhibitor from  centipede venom with analgesic efficacy exceeding morphine in rodent pain models. PNAS

[2] Murray JK., et al. (2015) Engineering Potent and Selective Analogs of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel. J Med Chem.